MHC-TP

MHC-TP v2.0.3

Peptide cluster to allotype motif correlation report.

Gibbs Cluster and Reference Motif ComparisonsiEach GibbsCluster motif (left) is paired with its best-matching reference allotype motif (right), ranked by Pearson correlation (PCC). Pick a cluster solution from the dropdown, then use the arrows or dots to step through its clusters. Allele names match the reference logo titles.

Each cluster solution's GibbsCluster motifs paired with the best-matching reference allotype motif. Use the arrows to step through clusters.

Cluster solution

Results for 1 cluster · 1 motif

1 of 1

1of1 best match HLA-A25:31 · PCC 0.745 · KLD 7.577

Gibbs cluster 1of1

Reference motif · HLA-A25:31

Results for 2 clusters · 2 motifs

1 of 2

1of2 best match HLA-B3919 · PCC 0.773 · KLD 4.108

Gibbs cluster 1of2

Reference motif · HLA-B3919

2of2 best match HLA-B1589 · PCC 0.777 · KLD 4.446

Gibbs cluster 2of2

Reference motif · HLA-B1589

Results for 3 clusters · 3 motifs

1 of 3

1of3 best match HLA-B39:92 · PCC 0.871 · KLD 2.366

Gibbs cluster 1of3

Reference motif · HLA-B39:92

2of3 best match HLA-B5309 · PCC 0.867 · KLD 3.771

Gibbs cluster 2of3

Reference motif · HLA-B5309

3of3 best match HLA-A6807 · PCC 0.728 · KLD 2.738

Gibbs cluster 3of3

Reference motif · HLA-A6807

Results for 4 clusters · 4 motifs

1 of 4

1of4 best match HLA-A6807 · PCC 0.747 · KLD 2.447

Gibbs cluster 1of4

Reference motif · HLA-A6807

2of4 best match HLA-B39:124 · PCC 0.876 · KLD 1.960

Gibbs cluster 2of4

Reference motif · HLA-B39:124

3of4 best match HLA-B44:257 · PCC 0.842 · KLD 1.893

Gibbs cluster 3of4

Reference motif · HLA-B44:257

4of4 best match HLA-B15:418 · PCC 0.806 · KLD 2.540

Gibbs cluster 4of4

Reference motif · HLA-B15:418

Results for 5 clusters · 4 motifs

1 of 4

1of5 best match HLA-A68:117 · PCC 0.827 · KLD 1.764

Gibbs cluster 1of5

Reference motif · HLA-A68:117

2of5 best match HLA-B39:124 · PCC 0.893 · KLD 1.842

Gibbs cluster 2of5

Reference motif · HLA-B39:124

3of5 best match HLA-B44:332 · PCC 0.837 · KLD 1.767

Gibbs cluster 3of5

Reference motif · HLA-B44:332

5of5 best match HLA-A25:51 · PCC 0.776 · KLD 1.996

Gibbs cluster 5of5

Reference motif · HLA-A25:51

Results for 6 clusters · 5 motifs

1 of 5

1of6 best match HLA-B44:65 · PCC 0.837 · KLD 1.704

Gibbs cluster 1of6

Reference motif · HLA-B44:65

3of6 best match HLA-C12:183 · PCC 0.745 · KLD 1.015

Gibbs cluster 3of6

Reference motif · HLA-C12:183

4of6 best match HLA-B39:124 · PCC 0.888 · KLD 1.372

Gibbs cluster 4of6

Reference motif · HLA-B39:124

5of6 best match HLA-A25:40 · PCC 0.792 · KLD 1.944

Gibbs cluster 5of6

Reference motif · HLA-A25:40

6of6 best match HLA-A68:165 · PCC 0.786 · KLD 1.469

Gibbs cluster 6of6

Reference motif · HLA-A68:165

Top 3 Allotype Matches per ClusteriFor each GibbsCluster motif, the top 3 reference allotypes scoring above the PCC threshold, all interleaved and ranked best first. PCC is the Pearson correlation between the cluster and reference position-weight matrices (1.0 = identical motif). KLD is the GibbsCluster Kullback–Leibler divergence (motif information content). Search by cluster id or allotype.

Each cluster's 3 best-matching allotypes above the PCC threshold, ranked overall.

#	Cluster	Best HLA/MHC	PCC	KLD
1	2of5	HLA-B39:124	0.893	1.842
2	2of5	HLA-B3942	0.890	1.842
3	2of5	HLA-B39:82	0.889	1.842
4	4of6	HLA-B39:124	0.888	1.372
5	4of6	HLA-B39:52	0.883	1.372
6	4of6	HLA-B3942	0.882	1.372
7	2of4	HLA-B39:124	0.876	1.960
8	2of4	HLA-B39:47	0.872	1.960
9	2of4	HLA-B39:52	0.871	1.960
10	1of3	HLA-B39:92	0.871	2.366
11	1of3	HLA-B39:66	0.867	2.366
12	2of3	HLA-B5309	0.867	3.771
13	1of3	HLA-B39:69	0.863	2.366
14	2of3	HLA-B53:40	0.859	3.771
15	2of3	HLA-B1513	0.852	3.771
16	3of4	HLA-B44:257	0.842	1.893
17	3of4	HLA-B44:103	0.838	1.893
18	3of4	HLA-B44:188	0.838	1.893
19	1of6	HLA-B44:65	0.838	1.704
20	1of6	HLA-B44:332	0.837	1.704
21	3of5	HLA-B44:332	0.837	1.767
22	3of5	HLA-B44:65	0.836	1.767
23	1of6	HLA-B4429	0.835	1.704
24	3of5	HLA-B44:300	0.835	1.767
25	1of5	HLA-A68:117	0.827	1.764
26	1of5	HLA-A68:45	0.827	1.764
27	1of5	HLA-A6829	0.815	1.764
28	4of4	HLA-B15:418	0.806	2.540
29	4of4	HLA-B1513	0.806	2.540
30	4of4	HLA-B1589	0.801	2.540
31	5of6	HLA-A25:40	0.792	1.944
32	5of6	HLA-A25:41	0.792	1.944
33	5of6	HLA-A25:45	0.792	1.944
34	6of6	HLA-A68:165	0.786	1.469
35	6of6	HLA-A68:85	0.784	1.469
36	6of6	HLA-A68:83	0.783	1.469
37	2of2	HLA-B1589	0.777	4.446
38	5of5	HLA-A25:51	0.776	1.996
39	5of5	HLA-A25:53	0.776	1.996
40	5of5	HLA-A25:57	0.776	1.996
41	2of2	HLA-B5309	0.775	4.446
42	2of2	HLA-B15:418	0.773	4.446
43	1of2	HLA-B3919	0.773	4.108
44	1of2	HLA-B39:121	0.768	4.108
45	1of2	HLA-B39:69	0.759	4.108
46	1of4	HLA-A6807	0.747	2.447
47	1of1	HLA-A25:31	0.745	7.577
48	1of1	HLA-A25:32	0.745	7.577
49	1of1	HLA-A25:34	0.745	7.577
50	3of6	HLA-C12:183	0.745	1.015
51	3of6	HLA-C12:90	0.736	1.015
52	3of6	HLA-C12:213	0.731	1.015
53	3of3	HLA-A6807	0.728	2.738
54	1of4	HLA-A68:105	0.726	2.447
55	1of4	HLA-A6806	0.725	2.447
56	3of3	HLA-A68:88	0.715	2.738
57	3of3	HLA-A6817	0.712	2.738

Correlation AnalysisiInteractive views of every cluster↔allotype correlation. Drag the PCC threshold to hide weaker matches. The Heatmap colours each pair by PCC; the Network links clusters to their correlated allotypes. The Combined tab stacks both.

PCC threshold 0.70

Combined Heatmap Network

HeatmapiColour encodes the PCC (0–1) for each cluster × allotype pair above the threshold. Darker = stronger match. Hover a cell for exact values.

NetworkiForce-directed graph: each cluster (large coloured node) links to the allotypes it correlates with; edge width scales with PCC. Drag nodes, scroll to zoom, hover for details.